Chinese scientists reveal why Zika virus causes artist wristband coachella pricemicrocephaly

Author:Chinese scientists reveal why Zika virus causes artist wristband coachella pricemicrocephaly2018-5-5 09:34:10

Packing Your Festival Essentials As Central Virginia families plan for the upcoming Labor Day weekend, there are a lot of possibilities. For hundreds of local families, this will be a somber holiday weekend. Undoubtedly you will want the event sport wristbands to be centred on those to whom you are going to address. Each specific type of audience will have different issues and interests. Billy Draws Two"s biggest accomplishment to date musically, according to Billy Horn, is "the fact that I"ve written songs that people enjoy enough to learn the lyrics and sing along with". The Agricenter is hosting the Delta Fair and festival wristbands on August 31-September 9. You will know you are there when you smell the funnel cakes and corn dogs that give you the full fair food experience. As you enter the park purchase a wrist band so that you can enjoy everything that the fair has to offer. Browse through the many arts and crafts vendors. There is a ride for everyone to enjoy and there is a kid zone that offers fun for everyone to enjoy with the kids. You will be amazed by all of the roaming fair entertainers and taking aback when you see two people eating away at watermelons for a prize. At the end of the evening make sure to stop and take in the lights of the fair. This is definitely the top pick of things to do for Labor Day Weekend. WHERE ARE YOU GOING TO HAVE YOUR event wristbands? Location is usually the area of the least control. Some locations require a reservation a year in advance, so you can not wait until the last minute. Researching locations 18 - 24 months in advance may help relieve a lot of stress early on. I you are having the party at your house then you just need to deal with the family. So weigh your odds early on! The next band I spoke with was Company. Company is a self-described indie rock sounding band. The band members are now living in Charleston, South Carolina. Used to playing empty bar rooms, Company is excited to be playing at the SXSW festival this year. You know what this means, right? In addition to the obvious outward physical improvements that movement provides, it also directly contributes to improvements in mood, learning, memory, focus, hormonal communication, immune function, and every other physical, mental and emotional function you can think of. True to it"s name, the bar is a few hundred feet west of South Broadway Street. Crime can be thick in this part of St. Louis, so be observant and don"t flash wads of cash to random dudes hangin" out in alleys. My first introduction to the venue was when a friend informed me she had been robbed walking from her car into the bar. Her sob story had a positive twist though, because the bartenders at Off Broadway fed her free drinks all night!

 

Luiz Philipe, who was born with microcephaly, sleeps in his house in Marica, Rio de Janeiro state, Brazil, on March 9, 2016. Brazil will adopt the World Health Organization (WHO) standards from the next week to determine if a baby has microcephaly, the Brazilian Health Ministry said on Wednesday. [Photo/Xinhua]


WASHINGTON -- Chinese researchers said Thursday they might have solved the mystery of why the Zika virus causes microcephaly, a birth defect marked by small head size that can lead to severe developmental problems in babies.

In a study published in the US journal Science, a team led by Cheng-Feng Qin of the Beijing Institute of Microbiology and Epidemiology reported that one single genetic change, likely acquired in 2013, gave the mosquito-borne virus the ability to cause severe fetal microcephaly.

"Our findings offer a reasonable explanation for the unexpected causal link of Zika to microcephaly, and will help understand how Zika evolved from an innocuous mosquito-borne virus into a congenital pathogen with global impact," Qin said.

Zika was first identified in 1947 in Uganda, and until its recent emergence in the Americas, was a little known one that sporadically causes mild infections.

Then, it rapidly swept through South and Central America in 2015, and due to its link to congenital brain abnormalities, especially microcephaly during pregnancy, the World Health Organization declared in early 2016 the current epidemics a public health emergency of international concern.

However, scientists remain unable to determine why the virus evolved into a pathogen triggering severe neurological syndromes.

By comparing contemporary Zika virus strains from the 2015 and 2016 South American epidemics with an ancestral Cambodian virus that was circulating in 2010, Qin and colleagues found one critical mutation that conferred the ability to cause microcephaly in mouse models of fetal infection.

That one change, S139N, which replaced a serine amino acid with an asparagine at the 139th position of a Zika protein called prM, also made the virus more lethal to human neuron precursor cells in culture compared with the ancestral form.

Zika accumulated numerous changes throughout its genome between 2010 and 2016, of which S139N caused substantially more severe microcephaly and embryonic lethality in mouse models.

Evolutionary analyses revealed that the S139N change likely arose sometime around 2013, which coincided with initial reports of microcephaly.

It was then stably maintained during subsequent spread to the America.

"The discovery should provide guidance for the study of pathogenetic mechanisms of the Zika virus and for the development of vaccines and treatments," Qin said.